abstract：:LIGHT is known to act as a novel mediator for atherogenesis. Furthermore, it has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells. However, it is not known if emodin exerts anti-atherogenic effects in the human monocyte, THP-1, following treatment with LIGHT. I...

journal_title：Vascular pharmacology

authors： Heo SK,Yun HJ,Noh EK,Park SD

更新日期：2010-07-01 00:00:00

abstract：:The heart is subjected to chronic mechanical unloading during prolonged spaceflight and microgravity. The heart in patients with end-stage heart failure is also unloaded in prolonged duration after left ventricular assist devices (LVAD) are implanted. Heterotopic heart transplantation in rats is an established model o...

journal_title：Vascular pharmacology

authors： Ito K,Kagaya Y,Shimokawa H

更新日期：2010-03-01 00:00:00

abstract：:Genetic mutations in bone morphogenetic protein receptor 2 (BMPR2) have been shown to occur in patients with familial and idiopathic pulmonary arterial hypertension (PAH). However the interactions between ligands for this receptor and other mediators implicated in heritable PAH have not been investigated. This study e...

journal_title：Vascular pharmacology

authors： Din S,Sarathchandra P,Yacoub MH,Chester AH

更新日期：2009-11-01 00:00:00

abstract：:A large number of studies utilize animal models to investigate therapeutic angiogenesis. However, the lack of a standardized experimental model leaves the comparison of different studies problematic. To establish a reference model of prolonged moderate tissue ischemia, we created unilateral hind limb ischemia in athym...

journal_title：Vascular pharmacology

authors： Yang Z,von Ballmoos MW,Diehm N,Baumgartner I,Kalka C,Di Santo S

更新日期：2009-10-01 00:00:00

abstract：:Results of our previous studies have suggested that enhanced generation of superoxide (O2(-)) may contribute to the pathophysiology of hypertension in Ren-2 transgenic rats (TGR). The present study was performed to evaluate in TGR the effects of chronic treatment with the O2(-) scavenger tempol and the antioxidant apo...

journal_title：Vascular pharmacology

authors： Kopkan L,Husková Z,Vanourková Z,Thumová M,Skaroupková P,Malý J,Kramer HJ,Dvorák P,Cervenka L

更新日期：2009-08-01 00:00:00

abstract：:There is little information about the direct effect of caffeine in human blood vessels. The purpose of this study was to evaluate the direct vascular effect of caffeine on human internal mammary artery (IMA) and the involvement of potassium channels in this response. Segments of IMA were obtained from 29 patients who ...

journal_title：Vascular pharmacology

authors： Montes FR,Cabrera M,Delgadillo A,Salgar C,Echeverri D

更新日期：2009-03-01 00:00:00

abstract：:Animal studies have identified monocyte chemoattractive protein-1 (MCP-1) and vascular endothelial growth factor (VEGF) as critical mediators of arterial diameter enlargement in response to chronic increases in blood flow (arteriogenesis). Furthermore, cellular studies have shown that the shear stresses resulting from...

journal_title：Vascular pharmacology

authors： Cannon JG,Sabatier MJ,Marinik EL,Schwark EH,Haddow S,Cortez-Cooper M,Bergeron MF,Sloan GJ,McCully KK

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Altered endothelial cell (EC)-derived mediator levels, including increased endothelin-1 (ET-1), are hallmarks of human pulmonary arterial hypertension (PAH). Gene mutations for receptors for bone morphogenic proteins (BMP), or transforming growth factor-beta (TGF-beta) cause heritable PAH. The effects of BMP...

journal_title：Vascular pharmacology

authors： Star GP,Giovinazzo M,Langleben D

更新日期：2009-01-01 00:00:00

abstract：:We investigated the effects of epinephrine and dopamine on retinal blood vessels in streptozotocin (STZ, 80 mg/kg, i.p.)-treated rats and age-matched control rats to determine whether diabetes mellitus alters the retinal vascular responses to circulating catecholamines. Experiments were performed 6-8 weeks after treat...

journal_title：Vascular pharmacology

authors： Nakazawa T,Sato A,Mori A,Saito M,Sakamoto K,Nakahara T,Ishii K

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Platelets play crucial roles in the development of arterial thrombosis and other pathophysiologies leading to clinical ischemic events. Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis. The purposes of the study are to determine whether atherosclerotic pl...

journal_title：Vascular pharmacology

authors： Li S,Li X,Li Y

更新日期：2008-07-01 00:00:00

abstract：:Our previous studies in heterozygous Ren-2 transgenic rats (TGR) have shown that early treatment with selective endothelin (ET)(A) receptor blockade is superior to nonselective ET(A/B) receptor blockade. The aim of this study was to evaluate the role of the ET system in male heterozygous TGR with established hypertens...

journal_title：Vascular pharmacology

authors： Vernerová Z,Kramer HJ,Bäcker A,Cervenka L,Opocenský M,Husková Z,Vanourková Z,Eis V,Chábová VC,Tesar V,Malý J,Vanecková I

更新日期：2008-04-01 00:00:00

abstract：:Urokinase plasminogen activator (uPA) system is important for several biological processes that call for extracellular proteolysis, fibrinolysis, cell migration, proliferation and angiogenesis. The current study highlights the fibrinolytic and wound healing potential of emodin, an anthraquinone, with relevance to the ...

journal_title：Vascular pharmacology

authors： Radha KS,Madhyastha HK,Nakajima Y,Omura S,Maruyama M

更新日期：2008-04-01 00:00:00

abstract：:The present study was designed to investigate the roles of enhanced arginase activity due to up-regulated arginases and the decreased hydroxyarginine for accelerating intimal hyperplasia with hyperglycemia. Thirteen weeks after injection of alloxan or physiological saline, endothelial denudation of the carotid artery ...

journal_title：Vascular pharmacology

authors： Ishizaka M,Nagai A,Iwanaga M,Imamura M,Azuma H

更新日期：2007-11-01 00:00:00

abstract：:Endothelin (ET-1) is chronically elevated in diabetes. However, role of ET-1 in increased oxidative stress in type 2 diabetes is less clear. This study tested the hypotheses that: 1) oxidative stress markers are increased and total antioxidant capacity is decreased in diabetes, and 2) activation of ET(A) receptors med...

journal_title：Vascular pharmacology

authors： Elgebaly MM,Portik-Dobos V,Sachidanandam K,Rychly D,Malcom D,Johnson MH,Ergul A

更新日期：2007-08-01 00:00:00

abstract：:Ghrelin, a 28-amino acid peptide, known to exist in both acylated and des-acylated varieties, was identified as the first endogenous ligand of growth hormone secretagogue receptor in 1999. Various arteries are known to express ghrelin receptors, but the direct action of ghrelin on blood vessels has been unclear. In th...

journal_title：Vascular pharmacology

authors： Dimitrova DZ,Mihov DN,Wang R,Hristov KL,Rizov LI,Bolton TB,Duridanova DB

更新日期：2007-07-01 00:00:00

abstract：:The early stages of invasion are characterized by the extracellular proteolysis and the accumulation of specialized extracellular matrix (ECM) scaffold, that are responsible for the development of vascular bed, endothelial cell proliferation and invasion of tumour cells. The ground substance of provisional matrix cons...

journal_title：Vascular pharmacology

authors： Mathivadhani P,Shanthi P,Sachdanandam P

更新日期：2007-06-01 00:00:00

abstract：:In this study, we have investigated the actions of danshensu, an active, water-extractable component of the medicinal herb danshen (Salvia miltiorrhiza), on rat isolated coronary artery rings precontracted with 1 microM 5-hydroxytryptamine (5-HT) and its action compared to the water-extractable fraction of the herb. E...

journal_title：Vascular pharmacology

authors： Lam FF,Yeung JH,Chan KM,Or PM

更新日期：2007-04-01 00:00:00

abstract：:The antiatherosclerotic effects of the dihydropyridine-type calcium channel blocker, benidipine hydrochloride (benidipine), and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, pravastatin sodium (pravastatin), were compared in hypercholesterolemic rabbits. Male, New Zealand white rabbits were fed a 0.5% cho...

journal_title：Vascular pharmacology

authors： Takayama M,Matsubara M,Arakawa E,Takada C,Ina Y,Hasegawa K,Yao K

更新日期：2007-04-01 00:00:00

abstract：:Endothelial cell dysfunction is considered to be an early event which subsequently leads to vascular wall disorders. Ultrastructural studies indicate that the endothelial cell changes involve membrane damage, increased permeability, swelling and necrosis. The endothelial cell loss of function could be as a result of c...

journal_title：Vascular pharmacology

authors： Tesfamariam B,DeFelice AF

更新日期：2007-04-01 00:00:00

abstract：:We studied the mechanisms involved in the relaxation induced by nitric oxide (NO) donors, ruthenium complex ([Ru(terpy)(bdq)NO(+)](3+)-TERPY) and sodium nitroprusside (SNP) in denuded rat aorta. Both NO donors induced vascular relaxation independent of the agonist used in the pre-contraction. [Ru(terpy)(bdq)NO(+)](3+)...

journal_title：Vascular pharmacology

authors： Bonaventura D,de Lima RG,Vercesi JA,da Silva RS,Bendhack LM

更新日期：2007-03-01 00:00:00

abstract：:Cardiac muscle extends into mammalian pulmonary veins for variable distances according to species. This study has addressed the autonomic control of electrically paced cardiac muscle of the pulmonary vein of the rat. Contractile responses of Wistar rat pulmonary veins were investigated under isometric conditions in vi...

journal_title：Vascular pharmacology

authors： Sweeney CM,Jones JF,Bund SJ

更新日期：2007-03-01 00:00:00

abstract：:Poorly controlled diabetes in pregnancy, characterized by hypo- and hyperglycemia, is associated with adverse outcomes. We hypothesized that aberrant glucose levels affect vascular function in pregnancy. The effects of glucose concentration on constriction and endothelium-dependent relaxation in uterine arteries of no...

journal_title：Vascular pharmacology

authors： Chirayath HH,Wareing M,Taggart MJ,Baker PN

更新日期：2007-02-01 00:00:00

abstract：RATIONALE:We examined the role of Jak2 kinase phosphorylation in the development of pressure overload hypertrophy in mice subjected to transverse aortic constriction (TAC) and treated with tyrphostin AG490, a pharmacological inhibitor of Jak2. METHODS:Control mice (sham), subjected to TAC for 15 days (TAC) or to TAC a...

journal_title：Vascular pharmacology

authors： Beckles DL,Mascareno E,Siddiqui MA

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:This study examined the role of Na+/K+-ATPase in the vasodilator actions of nitric oxide (NO), S-nitrosothiols and the endothelium-dependent agonist, acetylcholine. METHODS:The vasodilator responses elicited by intravenous injections of (i) the NO-donors, sodium nitroprusside and MAHMA NONOate, (ii) the S-n...

journal_title：Vascular pharmacology

authors： Lewis SJ,Travis MD,Hashmi-Hill MP,Sandock K,Robertson TP,Bates JN

更新日期：2006-12-01 00:00:00

abstract：:Neurokinin(3) (NK(3)) receptors may regulate the airways primarily through actions on the nerves. In the periphery, airway parasympathetic ganglia neurons are depolarized following NK(3) receptor activation resulting subsequently in the facilitation of synaptic transmission. Such an effect may account for the excessiv...

journal_title：Vascular pharmacology

authors： Canning BJ

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:The major objective of the present study was to examine the cardioprotective effect of resveratrol, an antioxidant presents in red wine, in the rat after ischemia-reperfusion (I/R). DESIGN:The left coronary artery was in occlusion for 30 min followed by a 120 min reperfusion in anesthetized rats. Animals wer...

journal_title：Vascular pharmacology

authors： Shen M,Jia GL,Wang YM,Ma H

更新日期：2006-08-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR)alpha, gamma and beta/delta belong to the nuclear receptor family of ligand-activated transcription factors. PPARs heterodimerize with the retinoid X receptor (RXR) and then act as transcription factors to modulate the function of many target genes. PPARalpha, gamma an...

journal_title：Vascular pharmacology

authors： Touyz RM,Schiffrin EL

更新日期：2006-07-01 00:00:00

abstract：:To investigate mechanisms of protective effects of fenofibrate on the diabetic kidney, male Wistar rats were divided into control, untreated diabetes, and fenofibrate-treated (32 mg kg(-1) d(-1), 8 weeks) diabetes groups. Diabetes induced by streptozotocin (25 mg/kg) and a high-fat diet was characterized by the disord...

journal_title：Vascular pharmacology

authors： Chen LL,Zhang JY,Wang BP

更新日期：2006-05-01 00:00:00

abstract：INTRODUCTION:Growth factor therapy provides a therapeutic alternative for "no option" patients with coronary disease. Fibroblast Growth Factor-2 (FGF-2) predominantly stimulates angiogenesis, the growth of new capillaries, whereas Monocyte Chemoattractant Protein-1 (MCP-1) is considered an arteriogenic agent. We hypoth...

journal_title：Vascular pharmacology

authors： Heilmann C,Kostic C,Giannone B,Grawitz AB,Armbruster W,Lutter G,Beyersdorf F,Göbel H

更新日期：2006-05-01 00:00:00

abstract：:Activation of ATP-sensitive K+ channels (K ATP) during ischemia leads to arrhythmias and blockade of these channels exert antiarrhythmic action. In this study, we investigated the effects of HMR1098, a sarcolemmal K ATP channel blocker and 5-hydroxydeconoate (5-HD), a mitochondrial K ATP channel blocker on cardiac fun...

journal_title：Vascular pharmacology

authors： Gok S,Vural K,Sekuri C,Onur R,Tezcan A,Izanli A

更新日期：2006-04-01 00:00:00

abstract：:The purpose of this study was to determine if P-selectin, an adhesion molecule involved in the transendothelial movement of leukocytes, might also have a direct influence on the function of cells that come into contact with it. Human peripheral blood mononuclear cells were incubated on immobilized P-selectin or a cont...

journal_title：Vascular pharmacology

authors： Sloan CL,Sloan GJ,Cannon JG

更新日期：2006-03-01 00:00:00

abstract：:The prevention of cardiovascular disease is critically dependent on lipid-lowering therapy, including 3-hydroxymethyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), cholesterol absorption inhibitors, bile acid resins, fibrates, and nicotinic acid. Although these drugs are generally well tolerate...

journal_title：Vascular pharmacology

authors： Schmitz G,Langmann T

更新日期：2006-02-01 00:00:00

abstract：:Ion channels control electrical excitability in living cells. In mammalian heart, the opposing actions of Na(+) and Ca(2+) ion influx, and K(+) ion efflux, through cardiac ion channels determine the morphology and duration of action potentials in cardiac myocytes, thus controlling the heartbeat. The last decade has se...

journal_title：Vascular pharmacology

authors： Roepke TK,Abbott GW

更新日期：2006-02-01 00:00:00

abstract：:Much has been written about the potential of pharmacogenetic testing to inform therapy based on an individual's genetic makeup, and to decide the most effective choice of available drugs, or to avoid dangerous side effects. Currently, there is little hard data for either in the field of cardiovascular disease. The usu...

journal_title：Vascular pharmacology

authors： Humphries SE,Hingorani A

更新日期：2006-02-01 00:00:00

abstract：:Platelet adhesion to subendothelial types I and III collagens exposed upon vascular injury plays a crucial role in hemostasis and thrombosis. We previously identified a KOGEOGPK sequence (O for hydroxyproline) within type III collagen interacting with platelets, and demonstrated a strong inhibitory effect of the KOGEO...

journal_title：Vascular pharmacology

authors： Maurice P,Pires V,Amant C,Kauskot A,Da Nascimento S,Sonnet P,Rochette J,Legrand C,Fauvel-Lafeve F,Bonnefoy A

更新日期：2006-01-01 00:00:00

abstract：:We recently demonstrated that lipoic acid suppresses endotoxin-stimulated expression of inducible nitric oxide synthase and nitric oxide production in mouse macrophages. In this study, we tested whether lipoic acid suppresses these inflammatory mediators in the lungs of rats. Rats were assigned to receive either no sp...

journal_title：Vascular pharmacology

authors： De Marco VG,Bosanquet JP,Rawlani VR,Skimming JW

更新日期：2005-12-01 00:00:00

abstract：:In addition to its role as a vasoconstrictor, angiotensin II also acts as a potent growth factor by activating several tyrosine kinases, including Jak2. Interestingly, Jak2 has been linked to similar cardiovascular pathologies as have been previously linked to the renin-angiotensin system. Identifying the downstream t...

journal_title：Vascular pharmacology

authors： Wallace TA,Xia SL,Sayeski PP

更新日期：2005-11-01 00:00:00

abstract：:Four main vascular effects of hydrogen peroxide (H2O2) were studied in intact and rubbed aortic rings from WKY rats. In rings partially precontracted with phenylephrine: 1-30 microM H2O2 induced an increase of tone, 100 microM H2O2 produced a transient contraction followed by a fast-developing endothelium-independent ...

journal_title：Vascular pharmacology

authors： Gil-Longo J,González-Vázquez C

更新日期：2005-08-01 00:00:00

abstract：:The aim of the present study was to investigate the cardioprotective activity of sulindac as an aldose reductase inhibitor in the development of cardiomyopathy by non-invasive techniques; M-mode and Doppler echocardiography. Diabetes was induced by streptozotocin (45 mg/kg, iv) in the Sprague-Dawley rats. Echocardiogr...

journal_title：Vascular pharmacology

authors： Krishna KM,Gopal GS,Chalam CR,Madan K,Kumar VK,Prakash GJ,Annapurna A

更新日期：2005-08-01 00:00:00

abstract：:Thalidomide is an antiangiogenic drug and is clinically useful in a number of cancers. However, the molecular mechanism by which thalidomide exerts its antitumor effects is poorly understood. This study was designed to clarify the relationship between antiangiogenesis and antitumor effects of thalidomide and to explor...

journal_title：Vascular pharmacology

authors： Du GJ,Lin HH,Xu QT,Wang MW

更新日期：2005-08-01 00:00:00